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Department of Neuropathology

+49-228 287 11352
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Education/Degrees

1989-1997 Medical schools at the Universities of Aachen, Charité Berlin and Bonn.
1997  
Doctoral Thesis at the Charité, Humboldt University, Berlin
2004   Habilitation, University of Bonn

  

Academic and Clinical Career

06/1997 – 12/1997
Postdoctoral Fellow at the Dept. of Medical Genetics. Advisor: Prof. F.C. Luft, Franz-Volhard-Clinic, Humboldt University, Berlin
01/1998 – 06/1999
Resident, Dept. of Epileptology, University of Bonn
07/1999 – 12/1999 Resident, Dept. of Neuropathology, University of Bonn
01/2000 – 12/2001 Resident, Dept. of Pathology, University of Bonn
01/2002 – 01/2004  Head, Epilepsy Research Unit, Dept. of Neuropathology, University of Bonn
Since 02/2004 Assistant Medical Director, Department for Neuropathology, University of Bonn Medical Center
Since 07/2007 Associate Professor (tenured), Chair for Molecular Neuropathology, Dept. of Neuropathology, University of Bonn
Since 2013 Head of Section for Translational Epilepsy Research, Dept. of Neuropathology, University of Bonn
Since 2014 / 2015 Speaker of ‘Promotionskolleg’ SciMed (06/2014) and EKFS-NeuroImmunology (04/2016).

 

Awards

2003  Dr.-Volker-Helbig Prize for Epilepsy Research
2003 Young Investigator Award, International League Against Epilepsy
2004 Poster award at the Annual Meeting of the American Epilepsy Society

 

Most important publications

  1. Pabst M, Braganza O, Dannenberg H, Rosen J, van Loo K, Deisseroth K, Schoch S, Becker AJ, Beck H. (2016) Astrocytic intermediaries of septohippocampal cholinergic transmission. Neuron,  90(4): 853-865.

  2. Woitecki AM, Müller JA, van Loo KM, Sowade RF, Becker AJ, Schoch S. (2016) Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration. J. Neurosci. 36(9): 2561-2570. 

  3. Becker AJ, Wiestler OD, Figarella-Branger D, Blümcke I, Capper D. Ganglioglioma. In: WHO Classification of Tumours of the Central Nervous System, Louis DN, Ohgaki H, Wiestler OD et al. (eds.), pp. 138-141, IARC: Lyon, 2016. 

  4. Johnson MR*, et al.(...), Becker AJ*, Petretto E*. (2015) Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus. Nat. Commun., 6: 6031. doi: 10.1038/ncomms7031, 2015. (* co-corresponding authors) 

  5. Kulbida R, Wang Y, Mandelkow EM, Schoch S, Becker AJ, van Loo KM. (2015) Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice. Brain Struct. Funct., 220(5): 3067-3073. 

  6. Van Loo KMJ, Schaub C, Pitsch J, Kulbida R, Opitz T, Ekstein D, Dalal A, Urbach H, Beck H, Yaari Y, Schoch S, Becker AJ. (2015) Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1. Nat. Commun., Oct 26;6: 8688. doi: 10.1038/ncomms9688. 

  7. Alvarez-Baron E, Michel K, Mittelstaedt T, Opitz T, Schmitz F, Beck H, Dietrich D, Becker AJ, Schoch S. (2013) RIM3γ and RIM4γ regulate neuronal arborization. J. Neurosci., 33: 824-839. 

  8. Van Loo KM, Schaub C, Pernhorst K, Yaari Y, Beck H, Schoch S, Becker AJ. (2012) Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST). J. Biol. Chem., 287(19): 15489-15501. 

  9. Becker AJ, Pitsch J, Sochivko D, Staniek M, Campbell KP, Schoch S, Yaari Y, Beck H. (2008) Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy. J. Neurosci., 28: 13341-13353.

  10. Fassunke J, Majores M, Tresch A, Niehusmann P, Grote A, Schoch S, Becker AJ. (2008) Array analysis of epilepsy-associated gangliogliomas reveals expression patterns related to aberrant development of neuronal precursors. Brain, 131: 3034-3050.
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