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University Professor

Adresse:
Institute of Neuropathology, University of Bonn, Medical School, Sigmund-Freud Str. 25, D-53105, Bonn/Germany
Telefon:
+49-228 287 19109
Fax:
+49-228 287 19362
Send an email.

Weitere Informationen

Education/Degrees

1988-1990
Chemistry, University of Heidelberg, Prediploma (11/90)
1990-1994
Chemistry, University of Cologne, Diploma (04/94)
1997
PhD (11/97), Genetics, University of Cologne, Doctoral thesis advisor: Prof. G. Thiel

 

Academic Career

1997 – 2002
Post-doctoral fellow, Southwestern Medical Center at Dallas, Texas, USA, 2002, Prof. T.C. Südhof
2003 – 2009
Head of an independent research group at the Institute of Neuropathology, University of Bonn 
2003 – 2008
Emmy Noether independent research group
2008 Call for a W2 professorship in the Neurocure Cluster of Excellency, Berlin
since 01/09 
Head of an independent research group funded by the BMBF
since 05/09  W2 professorship at the University of Bonn, Medical School

  

Most important publications

  1. Pabst M, Braganza O, Dannenberg H, Hu W, Pothmann L, Rosen J, Mody I, van Loo K, Deisseroth K, Becker AJ, Schoch S, Beck H. (2016) Astrocyte Intermediaries of Septal Cholinergic Modulation in the Hippocampus. Neuron., May 18;90(4): 853-865. doi: 10.1016/j.neuron.2016.04.003. 

  2. Woitecki AMH, Müller JA, van Loo KMJ, Sowade RF, Becker AJ, Schoch S. (2016) Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration. J. Neurosci., 36: 2561–2570. 

  3. van Loo KMJ, Schaub C, Pitsch J, Kulbida R, Opitz T, Ekstein D, Dalal A, Urbach H, Beck H, Yaari Y, Schoch S, Becker AJ. (2015) Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1. Nat. Commun., 6: 8688. 

  4. Alvarez-Baron E, Michel K, Mittelstaedt T, Opitz T, Schmitz F, Beck H, Dietrich D, Becker AJ, Schoch S. (2013) RIM3γ and RIM4γ regulate neuronal arborization. J. Neurosci., 33: 824-839. 

  5. Pitsch J, Opitz T, Woitecki A, Borm V, Staniek M, Beck H, Becker AJ, Schoch S. (2012) The presynaptic active zone protein RIM1alpha controls epileptogenesis following status epilepticus. J. Neurosci., 32: 12384-12395. 

  6. Schoch S*, Mittelstaedt T, Kaeser PS, Padgett D, Feldmann N, Chevaleyre V, Castillo PE, Hammer RE, Han W, Schmitz F, Lin W, Südhof TC*. (2006) Redundant functions of RIM1 and RIM2 in Ca2+-triggered neurotransmitter release. EMBO J, 25(24): 5852-5863. *:Corresponding author 

  7. Lonart G, Schoch S, Kaeser PS, Larkin CJ, Sudhof TC & Linden DJ. (2003) Phosphorylation of RIM1alpha by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses. Cell 115, 49-60. 

  8. Schoch S*, Castillo PE*, Jo T, Mukherjee K, Geppert M, Wang Y, Schmitz F, Malenka RC, Südhof TC. (2002) RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature, 415: 321-326. *equal contribution 

  9. Castillo PE *, Schoch S *, Schmitz F, Sudhof TC & Malenka RC. (2002). RIM1alpha is required for presynaptic long-term potentiation. Nature, 415: 327-330. *equal contribution

  10. Schoch S, Deak F, Königstorfer A, Mozhayeva M, Sara Y, Südhof TC, Kavalali ET. (2001) SNARE function analyzed in synaptobrevin/VAMP knockout mice. Science, 294: 1117-1122.
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