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Senior group leader and University Professor

+49-228 43302 590
+49-228 43302 689
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Education/Degrees

1995  
B.Sc., Anatomy and Developmental Biology, University College London
1995   Degree, Biochemistry, FU Berlin
1999   Dr. rer. nat., Biology, Ruprecht-Karls-Universität Heidelberg
2009   Habilitation, Neurobiology, Ludwig-Maximilians-Universität München

 

Academic Career

1995 – 1999
PhD student, Cell Biology Program, EMBL, Heidelberg with Dr. C. Dotti
2000 – 2002 Postdoctoral research associate, University of California, San Francisco & Stanford University (both HHMI) with Prof. Dr. M. 
  Tessier-Lavigne (HFSP & EMBO Fellow)
2003 – 2011 Independent junior Research Group Leader on associate Professor level (C3), Max-Planck Institute for Neurobiology, Martinsried
Since April 2011 
Senior Research Group Leader on Full Professor level (W3), German Center for Neurodegenerative Diseases (DZNE), Bonn
Since April 2011 W3-Professor at the University of Bonn

 

Awards and Honors

2000 Long-Term Fellowship, EMBO, Heidelberg
2001 Long-Term Fellowship, Human Frontier Science Program, Strasbourg  
2003 Career Development Award, Human Frontier Science Program, Strasbourg
2007 Selected Top 100 heads of tomorrow, Initiative of the Government of Germany
2011 Schellenberg-Prize, IRP, Switzerland
2013 Elected EMBO-Member
2014 Elected Leopoldina member, the German National Academy of Sciences
2016 Gottfried Wilhelm Leibniz-Preis

 

Memberships, academic and professional functions

*Organizer of MPG meeting "Axon Degeneration", Berlin 2014

*Organizer of EMBO workshop “Cell Biology of the Neuron”, Crete 2011

* Chair of the Cold Spring Harbor Meeting on Axon Guidance,Synapse Plasticity & Regeneration, 2010 

* Organizer of the SFB-Symposium “Axon, Dendrites, Calcium channels” in 2006

* Organizer of the EU research training network meeting “Brain repair” in 2006

Most important publications

  1. Ruschel J, Hellal F, Flynn KC, Dupraz S, Elliott DA, Tedeschi A, Bates M, Sliwinski C, Brook G, Dobrindt K, Peitz M, Brüstle O, Norenberg MD, Blesch A, Weidner N, Bunge MB, Bixby JL, Bradke F. (2015). Systemic administration of epothilone B promotes axon regeneration and functional recovery. Science, 348: 347-352. 

  2. Flynn KC, Hellal F, Neukirchen D, Jacobs S, Tahirovic S, Dupraz S, Stern S,  Garvalov BK, Gurniak C, Shaw A, Meyn L, Wedlich-Söldner R, Bamburg JR, Small JV, Witke W, Bradke F. (2012). ADF/cofilin-mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain. Neuron, 76: 1091-1107. 

  3. Ertürk A, Mauch CP, Hellal F, Förstner F, Keck T, Becker K, Jährling N, Steffens H, Richter M, Hübener M, Kramer E, Kirchhoff F, Dodt HU, Bradke F. (2011) 3D imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury. Nature Medicine, 18: 166-171. 

  4. Hellal F, Hurtado A, Ruschel J, Flynn KC, Laskowski CJ, Umlauf M, Kapitein LC, Strikis D, Lemmon V, Bixby J, Hoogenraad CC, Bradke F. (2011). Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury. Science, 331: 928-931. 

  5. Neukirchen D, Bradke F. (2011). Cytoplasmic Linker Proteins Regulate Neuronal Polarization through Microtubule and Growth Cone Dynamics. J. Neurosci., 31: 1528-1538. 

  6. Enes J, Langwieser N, Ruschel J, Carballosa-Gonzalez MM, Klug A, Traut MH, Ylera B, Tahirovic S, Hofmann F, Stein V, Moosmang S, Hentall ID, Bradke F. (2010). Electrical activity suppresses axon growth through Cav1.2 channels in adult primary sensory neurons. Current Biology, 20: 1154-1164. 

  7. Tahirovic T, Hellal F, Garvalov BK, Chrostek-Grashoff A, Brakebusch C, Bradke F. (2010) Rac1 regulates neuronal polarization through the WAVE-complex. J. Neurosci., 30: 6930-6943. 

  8. Stiess M, Maghelli M, Kapitein L, Gomis-Rüth S, Wilsch-Bräuninger M, Hoogenraad CC, Tolić-Nørrelykke IM, Bradke F. (2010). Axon extension occurs independently of centrosomal microtubule nucleation. Science, 327: 704-707. 

  9. Ylera B, Ertürk A, Hellal F, Nadrigny F, Hurtado A, Tahirovic S, Oudega M, Kirchhoff F, Bradke F. (2009). Chronically injured adult sensory axons in the CNS acquire axon regenerative competence following a lesion of their peripheral process. Current Biology, 19: 930-936. Dispatch in Current Biology about this work.

  10. Ertürk A, Hellal F, Enes J, Bradke F. (2007). Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration. J. Neurosci., 27: 9169-9180. Commentaries in J. Neuroscience and Faculty of 1000.
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