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Research Group Leader

+49-228 43302-580
+49-228 43302 689
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Education/Degrees

2002  
Diplom Biologe (t.o.), University of Stuttgart
2007   Dr. rer. nat. (Summa cum laude), Technical University of Munich 

 

Academic Career

2002 - 2006  
PhD Thesis, Center of Neuropathology and Prion Research, LMU Munich. Characterization of prion protein (PrP) function by 
  electrophysiological analysis of PrP knockout mice and in vivo two-photon imaging of structural dendritic spine plasticity in prion-infected mice
2007 – 2010  
Postdoctoral fellow, Center of Neuropathology and Prion Research, LMU Munich. Synapse loss and neuro-glial interaction in various 
  neurodegenerative disease mouse models analyzed by in vivo two-photon imaging
Since 2010   Research Group Leader, German Center for Neurodegenerative Diseases (DZNE).

 

Awards and Honors

2007  
2nd best project evaluation Forprion
2009   Körber Stiftung – Best German PhD thesis 2008

 

Most important publications

  1. Schmid LC, Mittag M, Poll S, Steffen J, Wagner J, Geis HR, Schwarz I, Schmidt B, Schwarz MK, Remy S, Fuhrmann M. (2016). Dysfunction of Somatostatin-PositiveInterneurons Associated with Memory Deficits in an Alzheimer's Disease Model. Neuron, 92(1):114-125. 

  2. Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, Leonov A, Kleinknecht A, Göricke B, Weishaupt JH, Weckbecker D, Reiner AM, Zinth W, Levin J, Ehninger D, Remy S, Kretzschmar HA, Griesinger C, Giese A, Fuhrmann M. (2015). Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies. Acta Neuropathol., (5): 619-631. 

  3. Fuhrmann F, Justus D, Sosulina L, Kaneko H, Beutel T, Friedrichs D, Schoch S, Schwarz MK, Fuhrmann M, Remy S. (2015) Locomotion, Theta Oscillations, and the Speed-Correlated Firing of Hippocampal Neurons Are Controlled by a Medial Septal Glutamatergic Circuit. Neuron, 86(5): 1253-1264. 

  4. Gu L, Kleiber S, Schmid L, Nebeling F, Chamoun M, Steffen J, Wagner J, Fuhrmann M. (2014) Long-term in vivo imaging of dendritic spines in the hippocampus reveals structural plasticity. J. Neurosci., 34(42): 13948-13953. 

  5. Bittner T, Burgold S, Dorostkar MM, Fuhrmann M, Wegenast-Braun BM, Schmidt B, Kretzschmar H, Herms J. (2012) Amyloid plaque formation precedes dendritic spine loss. Acta Neuropathol., 124(6):797-807. 

  6. Fuhrmann M, Bittner T, Jung CK, Burgold S, Page RM, Mitteregger G, Haass C, LaFerla FM, Kretzschmar H, Herms J. (2010) Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nat. Neurosci., 13(4): 411-413. 

  7. Bittner T, Fuhrmann M*, Burgold S, Ochs SM, Hoffmann N, Mitteregger G, Kretzschmar H, LaFerla FM, Herms J. (2010) Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice. PLoS One, 5(11):e15477 (* equal contribution) 

  8. Bittner T, Fuhrmann M, Burgold S, Jung CK, Volbracht C, Steiner H, Mitteregger G, Kretzschmar HA, Haass C, Herms J. (2009) Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway. J. Neurosci., 29(33): 10405-10409. 

  9. Fuhrmann M, Mitteregger G, Kretzschmar H, Herms J. (2007) Dendritic pathology in prion disease starts at the synaptic spine. J. Neurosci., 27(23): 6224-6233. PubMed PMID: 17553995

  10. Fuhrmann M, Bittner T, Mitteregger G, Haider N, Moosmang S, Kretzschmar H, Herms J. (2006) Loss of the cellular prion protein affects the Ca2+ homeostasis in hippocampal CA1 neurons.
    J. Neurochem.
    ,98(6):1876-85.
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