B01 Dendritic interaction of excitatory and inhibitory synaptic signals in intact and degenerated dendrites of pyramidal neurons
The computational properties of complex dendrites determine whether synaptic input is transformed into action potential output allowing the communication between neuronal partners in a network. About 90% of neuronal surface is formed by small caliber dendritic branches, which harbor thousands of excitatory and inhibitory synaptic sites. Whether a neuron discharges a single or a burst of action potentials and successfully communicates with its network partners in response to dendritic input depends both on (I) the functional properties of dendritic ion channels and (II) the interplay of excitation and inhibition. In this project we will investigate how the integration of excitatory and inhibitory synaptic input and the generation of neuronal output are altered in a transgenic mouse model of Alzheimer’s disease and whether alterations of dendritic function contribute to aberrant network excitability in this disease.