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B03 Role of NMDA co-agonists in local dendritic integration in normal and epileptic hippocampus

Neurons integrate excitatory synaptic inputs at their dendrites and transform them into action potential output. The input-output properties of neurons and their plasticity are modulated in many ways by the activation of N-methyl-D-aspartate receptors (NMDARs). NMDAR activation requires not only binding of the agonist glutamate and membrane depolarization to alleviate the Mg2+-block of the receptor, but also the binding of a co-agonist to the NMDAR. By combining cutting edge electrophysiology, multiphoton photomanipulation and imaging, as well as optogenetic techniques, we will address how the NMDAR co-agonist system regulates dendritic integration and plasticity, both in the normal and epileptic brain.