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C01 Inhibitory control of hippocampal network activity under healthy and Alzheimer's disease conditions

Learning and memory are substantial for our everyday life since they are the prerequisite for decision based orientation and navigation in space and time. Episodic memory is a hippocampus-dependent form of memory that describes the ability to recall specific past events about what, where and when an event has occurred. Inhibition is thought to be critically important in structuring sequences of principal neuron firing associated with memory encoding and recall. This project will determine how dysfunction of inhibitory microcircuits in Alzheimer's disease contributes to the amnestic phenotype of this disorder using a combination of optogenetic approaches, hippocampal two-photon in-vivo imaging, and behavioral paradigms. These studies are intended to pave the way towards manipulations that may improve cognitive performance in Alzheimer's disease models.