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In a study published in the journal Neuron, researchers from the group of Dr. Martin Fuhrmann report on the role of hippocampal interneurons in Alzheimer’s disease.
They identify synaptic rewiring deficits on the input and output side of O-LM interneurons during disease progression. Moreover, synaptic adaptations on O-LM interneurons due to fear learning are disturbed in a model of Alzheimer’s disease. The explanation for this defect is a reduced cholinergic input from the medial septum that is required for learning-dependent rewiring on O-LM interneurons.