Dr. Karen M.J. van Loo

Postdoctoral fellow

Mailing Address:

Department of Neuropathology,
University of Bonn,
Medical Center,
Sigmund-Freud-Str. 25,
53105, Bonn/Germany

Phone:

+49-228-287 19346; +49-228-287 19362

Email:

karen.van_loo@ukb.uni-bonn.de

Weitere Informationen

Education/Degrees

1997 – 2000 Bachelor of Science, Biology, Radboud University Nijmegen, The Netherlands
2000 – 2002 Master Medical Biology, Radboud University Nijmegen, The Netherlands
2002 – 2006 PhD-student, Dept. of Molecular Animal Physiology, Radboud University Nijmegen, The Netherlands

Academic Career

2007 – 2008 Postdoctoral fellow, Dept. of Molecular Animal Physiology, Radboud University Nijmegen, The Netherlands
Since 2009 Postdoctoral fellow, Dept. of Neuropathology, University of Bonn

Memberships and professional functions

* Member, Dutch Neurofederation

Most important publications

  1. Pabst M, Braganza O, Dannenberg H, Rosen J, van Loo K, Deisseroth K, Schoch S, Becker A, Beck H. (2016) Astrocytic intermediaries of septohippocampal cholinergic transmission.Neuron, 90(4): 853-865.
  2. Woitecki AM, Müller JA, van Loo KM, Sowade RF, Becker AJ, Schoch S. (2016) Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration. J. Neurosci., 36(9): 2561-2570.
  3. van Loo KM, Schaub C, Pitsch J, Kulbida R, Opitz T, Ekstein D, Dalal A, Urbach H, Beck H, Yaari Y, Schoch S, Becker AJ. (2015) Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1. Nat. Commun., 6: 8688.
  4. Kulbida R, Wang Y, Mandelkow EM, Schoch S, Becker AJ, van Loo KM. (2015) Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice.Brain Struct. Funct., 220(5): 3067-3073.
  5. Ekstein D, Benninger F, Daninos M, Pitsch J, van Loo KM, Becker AJ, Yaari Y. (2012) Zinc induces long-term upregulation of T-type calcium current in hippocampal neurons in vivo. J. Physiol., 2012 Nov 15;590(22): 5895-5905.
  6. van Loo KM, Schaub C, Pernhorst K, Yaari Y, Beck H, Schoch S, Becker AJ. (2012) Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST). J. Biol. Chem., 287(19): 15489-15501.
  7. Verheij MM, de Mulder EL, De Leonibus E, van Loo KM, Cools AR. (2008) Rats that differentially respond to cocaine differ in their dopaminergic storage capacity of the nucleus accumbens. J. Neurochem., 105(6): 2122-2133.
  8. Coolen MW, van Loo KM, Ellenbroek BA, Cools AR, Martens GJ. (2006) Ontogenic reduction of Aph-1b mRNA and gamma-secretase activity in rats with a complex neurodevelopmental phenotype. Mol. Psychiatry., 1(8): 787-793.
  9. Coolen MW, van Loo KM, van Bakel NN, Ellenbroek BA, Cools AR, Martens GJ. (2006) Reduced Aph-1b expression causes tissue- and substrate-specific changes in gamma-secretase activity in rats with a complex phenotype. FASEB J., 20(1): 175-177.
  10. Coolen MW, van Loo KM, Van Bakel NN, Pulford DJ, Serneels L, De Strooper B, Ellenbroek BA, Cools AR, Martens GJ. (2005) Gene dosage effect on gamma-secretase component Aph-1b in a rat model for neurodevelopmental disorders. Neuron., 45(4): 497-503.