The role of long-range inhibitory projections for learning and memory deficits under AD-like conditions
Long-range inhibitory projections have been shown to facilitate information processing between the entorhinal cortex and the hippocampus. We have previously shown that local GABAergic neurons in the hippocampus are impaired under Alzheimer’s disease like conditions. Decreased cholinergic input from the medial septum during associative learning disturbed the formation of learning-induced dendritic spines on O-LM interneurons. In the current project, we will investigate whether long-range inhibitory projections between the entorhinal cortex and the hippocampus contribute to memory dysfunction in a mouse model of amyloidosis.