A05 Dentate gyrus activity patterns and their intra-hippocampal coordination in behavior and disease
This project will use genetic and chemogenetic manipulation of entorhinal stellate, dentate granule and dentate mossy cells in the hippocampus to study their role in memory acquisition and consolidation. Specifically, it will explore the contribution and interaction of these cells in the expression and coordination of signatures of memory consolidation, such as hippocampal oscillations and sharp-waves as well as dentate sharp-waves, across a range of natural behaviors and tasks. Finally, the tools developed will be applied to analyze chronic silicon probe recordings from a novel patient-derived HCN1 epilepsy mouse model that expresses histopathological changes in the dentate gyrus.
https://www.dzne.de/forschung/forschungsbereiche/grundlagenforschung/forschungsgruppen/isbrandt