A04
A04 Synaptic Microcircuitry during Axon Regeneration: The Role of Rehabilitation in Modulating Neuronal Tracts and Behavioral Outcomes Following Microtubule Stabilisation Treatment
This project will continue to address mechanisms of axonal regeneration in the CNS, using spinal cord injury as a model. The project has shown already that systemic administration of the microtubule stabilizing drugs epothilone B and epothilone D induces axon regeneration and functional recovery after a spinal cord injury. The project will now elucidate how intense rehabilitation protocols affect both regeneration of synaptic micronetworks and behavioral recovery, the latter using high-precision behavioral readouts.