C01 Network alterations between hippocampus, entorhinal and prefrontal cortex contributing to spatial working memory impairment under AD-like conditions

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C01

Network alterations between hippocampus, entorhinal and prefrontal cortex contributing to spatial working memory impairment under AD-like conditions

This project hypothesizes that the connectivity in the extended hippocampal-prefrontal and entorhinal-prefrontal memory networks is impaired in Alzheimer’s disease models and contributes to spatial working memory deficits. This hypothesis will be examined using analysis of circuit connectivity combined with in-vivo multiphoton imaging and optogenetic manipulation in a working memory task.

 

https://www.dzne.de/forschung/forschungsbereiche/grundlagenforschung/forschungsgruppen/fuhrmann