A study led by the IEECR has identified a mechanism relying on Ste20-like kinase that allows single cortical neurons to cell-autonomously adjust feedforward inhibition they receive to the cell-specific levels of excitatory input. The authors propose that this mechanism is critical
Read moreMonth: December 2022
Paper in Brain out! Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy.
Memory deficits are a debilitating symptom of epilepsy, but little is known about mechanisms underlying cognitive deficits. Here, we describe a Na+ channel-dependent mechanism underlying altered hippocampal dendritic integration, degraded place coding, and deficits in spatial memory. Two-photon glutamate uncaging experiments
Read moreTargeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy. Paper in Brain out!
![Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy. Paper in Brain out! Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy. Paper in Brain out!](https://i0.wp.com/sfb1089.de/wp-content/uploads/2022/12/Nicola-Masala_Frei-1.jpg?resize=242%2C300&ssl=1)
Memory deficits are a debilitating symptom of epilepsy, but little is known about mechanisms underlying cognitive deficits. Here, we describe a Na+ channel-dependent mechanism underlying altered hippocampal dendritic integration, degraded place coding, and deficits in spatial memory. Two-photon glutamate uncaging experiments
Read more