An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from regenerating in the adult central nervous system (CNS). Here we show how the two aspects are interwoven. Genetic loss-of-function experiments determine that the small GTPase RhoA relays extracellular inhibitory signals to the cytoskeleton by adapting mechanisms
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CRC 1089 extended
We are happy and excited to announce that the DFG has extended funding for the CRC 1089 for another 4 years. In the CRC 1089, BCN scientists together with partners from the DZNE and caesar, as well as national and
Read moreA Protein that Pulls the Brake on Nerve Growth
Bonn/Germany, October 31, 2019. During embryonic development, nerve cells form thin, long extensions, which they use to wire up a complex network, the brain. Scientists from the German Center for Neurodegenerative Diseases (DZNE) in Bonn have now identified a protein
Read moreNew publication from Frank Bradke
SFB1089 member Prof. Bradke, who works at the German Center for Neurodegenerative Diseases (DZNE) and his group have identified a group of proteins that help to regenerate damaged nerve cells. Their findings are reported in the journal “Neuron”. It is
Read moreSFB1089 Member Frank Bradke to be awarded for research on neuronal regeneration
Bonn/Geneva, January, 30th, 2019. Frank Bradke, a senior researcher at the German Center for Neurodegenerative Diseases (DZNE) and a professor at the University of Bonn, will be awarded the Roger de Spoelberch Prize, which is endowed with 750,000 euros. The Swiss Roger
Read moreJobs at the SFB1089
The Sonderforschungsbereich 1089 (SFB 1089) on Synaptic Microcircuits in Health and Disease (www.sfb1089.de) has recently been renewed for funding by the Deutsche Forschungsgemeinschaft (DFG) and is looking to recruit PhD students (E13 65% TV-L) and postdoctoral scientists (E13 TV-L) starting as soon as possible and is
Read moreStefan Remy receives “CONSOLIDATOR GRANT”
Stefan Remy will receive the “Consolidator Grant” from the European Research Council worth 1.8 million. More information you can find here.
Read moreRabies viruses reveal wiring in transparent brains
Scientists under the leadership of the University of Bonn have harnessed rabies viruses for assessing the connectivity of nerve cell transplants: coupled with a green fluorescent protein, the viruses show where replacement cells engrafted into mouse brains have connected to
Read moreSpeed data for the brain’s navigation system
Bonn (Germany), December 6th, 2016. In order to guide us accurately through space, the brain needs a “sense” of the speed of our movement. But how do such stimuli actually reach the brain? Researchers at the German Center for Neurodegenerative
Read moreDysfunction of Somatostatin-Positive Interneurons Associated with Memory Deficits in an Alzheimer’s Disease Model
In a study published in the journal Neuron, researchers from the group of Dr. Martin Fuhrmann report on the role of hippocampal interneurons in Alzheimer’s disease. They identify synaptic rewiring deficits on the input and output side of O-LM interneurons
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