Prof. Dr. Frank Bradke, neurobiologist at the German Center for Neurodegenerative Diseases (DZNE) and professor at the University of Bonn, has been elected to the Berlin-Brandenburg Academy of Sciences and Humanities (BBAW). The induction ceremony took place on June 14, 2025,
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Prof. Frank Bradke Inducted into the North Rhine–Westphalia Academy of Sciences and Arts
Prof. Dr. Frank Bradke—Senior Group Leader at the DZNE and Professor at the University of Bonn—has been welcomed as a new member of the North Rhine–Westphalia Academy of Sciences and Arts. He received his certificate from the Academy’s President, Prof.
Read moreDZNE: AG Bradke unravels new insights into the role of the Centrosome in neuron migration. Now out in Neuron!
The growth and migration of neurons in the brain are the focus of a recent study. As nerve cells form, they wire the brain to allow communication with other nerve cells. The axon, one of the wires that form when
Read moreCircuit-selective cell-autonomous regulation of inhibition in pyramidal neurons by Ste20-like kinase paper in Cell Reports out.
A study led by the IEECR has identified a mechanism relying on Ste20-like kinase that allows single cortical neurons to cell-autonomously adjust feedforward inhibition they receive to the cell-specific levels of excitatory input. The authors propose that this mechanism is critical
Read morePaper in Brain out! Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy.
Memory deficits are a debilitating symptom of epilepsy, but little is known about mechanisms underlying cognitive deficits. Here, we describe a Na+ channel-dependent mechanism underlying altered hippocampal dendritic integration, degraded place coding, and deficits in spatial memory. Two-photon glutamate uncaging experiments
Read moreTargeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy. Paper in Brain out!
Memory deficits are a debilitating symptom of epilepsy, but little is known about mechanisms underlying cognitive deficits. Here, we describe a Na+ channel-dependent mechanism underlying altered hippocampal dendritic integration, degraded place coding, and deficits in spatial memory. Two-photon glutamate uncaging experiments
Read moreFrank Bradke awarded “Carl Zeiss Lecture”
Prof. Frank Bradke, research group leader at DZNE and a professor at the University of Bonn, will give this year’s “Carl Zeiss Lecture”. With this award, which has been presented since 1990, the German Society for Cell Biology (DGZ) recognizes outstanding
Read moreAG Bradke published an article about axon regeneration and astrocyte reactivity after CNS injury
An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from regenerating in the adult central nervous system (CNS). Here we show how the two aspects are interwoven. Genetic loss-of-function experiments determine that the small GTPase RhoA relays extracellular inhibitory signals to the cytoskeleton by adapting mechanisms
Read moreCRC 1089 extended
We are happy and excited to announce that the DFG has extended funding for the CRC 1089 for another 4 years. In the CRC 1089, BCN scientists together with partners from the DZNE and caesar, as well as national and
Read moreA Protein that Pulls the Brake on Nerve Growth
Bonn/Germany, October 31, 2019. During embryonic development, nerve cells form thin, long extensions, which they use to wire up a complex network, the brain. Scientists from the German Center for Neurodegenerative Diseases (DZNE) in Bonn have now identified a protein
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