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Author: admin

DZNE: AG Bradke unravels new insights into the role of the Centrosome in neuron migration. Now out in Neuron!

admin News February 22, 2023February 22, 2023

The growth and migration of neurons in the brain are the focus of a recent study. As nerve cells form, they wire the brain to allow communication with other nerve cells. The axon, one of the wires that form when

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Circuit-selective cell-autonomous regulation of inhibition in pyramidal neurons by Ste20-like kinase paper in Cell Reports out.

admin News December 8, 2022

A study led by the IEECR has identified a mechanism relying on Ste20-like kinase that allows single cortical neurons to cell-autonomously adjust feedforward inhibition they receive to the cell-specific levels of excitatory input. The authors propose that this mechanism is critical

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Paper in Brain out! Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy.

admin News December 7, 2022

Memory deficits are a debilitating symptom of epilepsy, but little is known about mechanisms underlying cognitive deficits. Here, we describe a Na+ channel-dependent mechanism underlying altered hippocampal dendritic integration, degraded place coding, and deficits in spatial memory. Two-photon glutamate uncaging experiments

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Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy. Paper in Brain out!

admin News December 6, 2022December 7, 2022
Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy. Paper in Brain out!

Memory deficits are a debilitating symptom of epilepsy, but little is known about mechanisms underlying cognitive deficits. Here, we describe a Na+ channel-dependent mechanism underlying altered hippocampal dendritic integration, degraded place coding, and deficits in spatial memory. Two-photon glutamate uncaging experiments

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Frank Bradke awarded “Carl Zeiss Lecture”

admin News November 3, 2021
Frank Bradke awarded “Carl Zeiss Lecture”

Prof. Frank Bradke, research group leader at DZNE and a professor at the University of Bonn, will give this year’s “Carl Zeiss Lecture”. With this award, which has been presented since 1990, the German Society for Cell Biology (DGZ) recognizes outstanding

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AG Bradke published an article about axon regeneration and astrocyte reactivity after CNS injury

admin News September 23, 2021

An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from regenerating in the adult central nervous system (CNS). Here we show how the two aspects are interwoven. Genetic loss-of-function experiments determine that the small GTPase RhoA relays extracellular inhibitory signals to the cytoskeleton by adapting mechanisms

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CRC 1089 extended

admin News June 15, 2021June 15, 2021

We are happy and excited to announce that the DFG has  extended funding for the CRC 1089 for another 4 years. In the CRC 1089, BCN scientists together with partners from the DZNE and caesar, as well as national and

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A Protein that Pulls the Brake on Nerve Growth

admin News November 4, 2019November 4, 2019

Bonn/Germany, October 31, 2019. During embryonic development, nerve cells form thin, long extensions, which they use to wire up a complex network, the brain. Scientists from the German Center for Neurodegenerative Diseases (DZNE) in Bonn have now identified a protein

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New publication from Frank Bradke

admin News August 14, 2019August 14, 2019

SFB1089 member Prof. Bradke, who works at the German Center for Neurodegenerative Diseases (DZNE) and his group have identified a group of proteins that help to regenerate damaged nerve cells. Their findings are reported in the journal “Neuron”. It is

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SFB1089 Member Frank Bradke to be awarded for research on neuronal regeneration

admin News February 4, 2019February 4, 2019

Bonn/Geneva, January, 30th, 2019.  Frank Bradke, a senior researcher at the German Center for Neurodegenerative Diseases (DZNE) and a professor at the University of Bonn, will be awarded the Roger de Spoelberch Prize, which is endowed with 750,000 euros. The Swiss Roger

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