SFB members discover a mesocortical inhibitory circuit

In the paper Function and developmental origin of a mesocortical inhibitory circuit, Dr. Sandra Blaess and members of the Laboratory of Experimental Epileptology and Cognition Research discover a mesocortical inhibitory circuit. This mesocortical circuit provides glutamatergic excitation of interneurons and inhibits pyramidal neurons in the prefrontal cortex. Moreover, they identified the subset of dopaminergic progenitors that generates these mesocortical neurons. Loss of these progenitors results in the loss of the inhibitory circuit and increased perseverative behavior. The findings were published in Nature neuroscience.

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