Dr. Sabine Krabbe

Dr. Sabine Krabbe


Principal Investigators


2003 – 2008 Diploma in Human Biology, Philips-University Marburg, Germany
2012 Doctoral thesis (Dr. rer. nat.), Goethe University Frankfurt & Philipps University Marburg, Germany

Academic Career:

2008 – 2011 Research assistant, Goethe University Frankfurt, Germany
2012 – 2020 Postdoctoral fellow, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Since 2018 Visiting scientist, HHMI Janelia Research Campus, Ashburn, USA
Since 2020 Junior Group Leader, German Center for Neurodegenerative Diseases e.V. (DZNE)


Awards and Honors:

2019                 Career Development Award, Synapsis Foundation – Alzheimer Research Switzerland ARS, Zürich, Switzerland

2018                 Janelia Visiting Scientist Scholarship, HHMI Janelia Research Campus, Ashburn, USA

2015                 NARSAD Young Investigator Award, Brain & Behavior Research Foundation, New York, USA

Memberships, academic and professional duties (selection):

Since 2013        Member of the Swiss Society for Neuroscience

Since 2008        Member of the Society for Neuroscience, USA

Since 2007        Member of the German Society for Neuroscience


List of 10 most important publications

  1. Krabbe S*, Paradiso E*, d’Aquin S, Bitterman Y, Courtin J, Xu C, Yonehara K, Markovic M, Eichlisberger T, Müller C, Gründemann J, Ferraguti F, Lüthi A. (2019) Adaptive disinhibitory gating by VIP interneurons permits associative learning. Neurosci., 22(11):1834-1843.
  2. Gründemann J, Bitterman Y, Lu T, Krabbe S, Grewe BF, Schnitzer M, Lüthi A. (2019) Amygdala ensembles encode behavioral states. Science, 364(6437):eaav8736.
  3. Krabbe S, Gründemann J, Lüthi A. (2018) Amygdala inhibitory circuits regulate associative fear conditioning. Psychiatry, 83(10):800-809.
  4. Fadok JP, Krabbe S, Markovic M, Courtin J, Xu C, Massi L, Botta P, Bylund K, Müller C, Tovote P, Lüthi A. (2017) A competitive inhibitory circuit for selection of active and passive fear responses. Nature, 542(7639):96-100.
  5. Xu C, Krabbe S, Gründemann J, Botta P, Fadok JP, Osakada F, Saur D, Grewe BF, Schnitzer MJ, Callaway EM, Lüthi A. (2016) Distinct hippocampal output pathways mediate dissociable roles of context in associative memory retrieval. Cell, 167(4):961-972.e16.
  6. Vogel E*, Krabbe S*, Gründemann J, Wamsteeker Cusulin JI, Lüthi A. (2016) Projection-specific dynamic regulation of inhibition in amygdala micro-circuits. Neuron, 91(3):644-51.
  7. Krabbe S, Duda J, Schiemann J, Poetschke C, Schneider G, Kandel ER, Liss B, Roeper J, Simpson EH. (2015) Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area. PNAS, 112(12):E1498-506.
  8. Wolff SB, Gründemann J, Tovote P, Krabbe S, Jacobson GA, Müller C, Herry C, Ehrlich I, Friedrich RW, Letzkus JJ, Lüthi A. (2014) Amygdala interneuron subtypes control fear learning through disinhibition. Nature, 509(7501):453-8.
  9. Tokay T, Rohde M, Krabbe S, Rehberg M, Bender, RA, Köhling R, Kirschstein T. (2009) HCN1 channels constrain DHPG-induced LTD at hippocampal Schaffer collateral-CA1 synapses. Mem., 16(12):769‐776.


Phone: 49 228 43302-769

Email: sabine.krabbe@dzne.de